MICHAEL O’DEA

GRADUATE STUDENT

michael.odea@nyulangone.org | @michaelrodea

Michael received his Bachelor of Science in Biological Sciences at the University of Notre Dame. As an undergraduate, he worked as a research assistant studying neuroendocrinology, examining the effects of psychosocial stress on the hypothalamic-pituitary-adrenal axis, while concurrently working in a translational cancer laboratory where he studied targeted therapy resistance in breast cancer. Discovering a passion for neuroscience and cell biology, Michael began research in cellular neuroscience in the laboratory of Dr. Cody Smith at the University of Notre Dame, exploring developmental microglia dynamics using intravital confocal microscopy in zebrafish.

As a graduate student in the Neuroscience & Physiology program at NYU Langone Medical Center, Michael is investigating astrocyte heterogeneity and how it interfaces with responses to disease or injury.

KEY PUBLICATIONS

(* = equal contribution)

  1. O’Dear MR, Hasel P (2024) Are we there yet? Exploring astrocyte heterogeneity one cell at a time. Glia. PMID: 39308429.

  2. Geraghty AC, Acosta-Alvarez L, Rotiroti M, Dutton S, O'Dea MR, Woo PJ, Xu H, Shamardani K, Mancusi R, Ni L, Mulinyawe SB, Kim WJ, Liddelow SA, Majzner RG, Monje M. Immunotherapy-related cognitive impairment after CAR T cell therapy in mice. bioRxiv 2024.05.14.594163

  3. Sadick JS*, O'Dea MR*, Hasel P, Dykstra T, Faustin A, Liddelow SA (2022) Astrocytes and oligodendrocytes undergo subtype-specific transcriptional changes in Alzheimer's disease. Neuron 110(11):1788-1805. PMID: 35381189.

  4. Fernández-Castañeda A, Lu P, Geraghty AC, Song E, Lee MH, Wood J, O'Dea MR, Dutton S, Shamardani K, Nwangwu K, Mancusi R, Yalçın B, Taylor KR, Acosta-Alvarez L, Malacon K, Keough MB, Ni L, Woo PJ, Contreras-Esquivel D, Toland AMS, Gehlhausen JR, Klein J, Takahashi T, Silva J, Israelow B, Lucas C, Mao T, Peña-Hernández MA, Tabachnikova A, Homer RJ, Tabacof L, Tosto-Mancuso J, Breyman E, Kontorovich A, McCarthy D, Quezado M, Vogel H, Hefti MM, Perl DP, Liddelow S, Folkerth R, Putrino D, Nath A, Iwasaki A, Monje M (2022) Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation. Cell 185(14):2452-2468. PMID: 35768006.

  5. Green LA*, O'Dea MR*, Hoover CA, DeSantis DF, Smith CJ (2022) The embryonic zebrafish brain is seeded by a lymphatic-dependent population of mrc1 + microglia precursors. Nat Neurosci PMID: 35710983.