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ANNIE MARCHILDON

RESEARCH ASSOCIATE

anne.marchildon@nyulangone.org | @AnnieMarchildon

Annie grew up on Long Island in a small town called Sea Cliff. As a student at North Shore High School, her interests in science research developed as she worked at the Feinstein Institute for Medical Research for two years. There, she completed an independent research project focusing on sensitizing glioblastoma stem cells to ionizing radiation, wrote a paper and submitted her findings to various state and national competitions.

She attended Cornell University as a Biological Sciences major in the College of Agriculture and Life Sciences. Annie completed multiple research internships within and between her college years, gaining interest in neuroscience research after her summer working with Dr. Kevin Tracey at the Feinstein Institute. There she focused on how ablating sensory TRPV1 neurons impacted T-cell and Dendritic cell’s responses to antigens. Her passion for neuroscience research expanded after joining Dr. Edmund Hollis’ lab at the Burke Neurological Institute in White Plains. There, Annie focused on how microglial cells are important for synaptic pruning and early motor learning skills. She utilized various behavioral tasks to compare the differences between total microglial knockout mice using the CX3CR1 fractalkine receptor. 

Annie is excited to expand her passions for combining immunology and neuroscience research, and she finds the world of microglia and astrocytes to be the perfect balance.

KEY PUBLICATIONS

  1. Frazel PW, Labib D, Fisher T, Brosh R, Pirianian N, Marchildon A, Boeke JD, Fossati V, Liddelow SA (2023) Longitudinal scRNA-seq analysis in mouse and human informs optimization of rapid mouse astrocyte differentiation protocols. Nat Neurosci 26(10):1726-1738. PMID: 37697111.

  2. Hasel P, Cooper ML, Marchildon AE, Rufen-Blanchette UA, Kim RD, Ma TC, Kang UJ, Chao MV, Liddelow SA. Defining the molecular identity and morphology of glia limitans superficialis astrocytes in mouse and human. bioRxiv 2023.04.06.535893.

  3. Kim RD, Marchildon AE, Frazel PW, Hasel P, Guo AX, Liddelow SA. Temporal and spatial analysis of astrocytes following stroke identifies novel drivers of reactivity. bioRxiv 2023.11.12.566710.